I am a
Home I AM A Search Login

Papers of the Week


Papers: 19 Oct 2024 - 25 Oct 2024


2024 Oct 17


Fundam Clin Pharmacol


39419628

Nociceptive TRP channels function as molecular target for several antifungal drugs.

Authors

Okabe S, Takahashi K, Hashimoto M, Ohta T

Abstract

Topically applied antifungal agents can induce adverse effects, such as pain and irritation. The transient receptor potential (TRP) channels-TRPA1 and TRPV1-mainly expressed in sensory neurons, act as sensors for detecting irritants. This study aims to evaluate the involvement of nociceptive channels in topical antifungal-induced pain and irritation. We tested nine topical antifungals belonging five classes: isoconazole, econazole, miconazole, clotrimazole, and ketoconazole as imidazoles; liranaftate as a thiocarbamate; terbinafine as an allylamine; amorolfine as a morpholine; and butenafine as a benzylamine.