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Papers of the Week

Papers: 28 Oct 2023 - 3 Nov 2023

2023 Nov 01

Nurs Res


Nociceptive and Transcriptomic Responses in a Swine Diabetic Wound Model Treated With a Topical AT1R Antagonist.


Weiss MN, Mocci E, Zhu S, Davenport MJ, English E, Renn CL, Dorsey SG


Painful, treatment-resistant wounds are prevalent among diabetic patients and significantly affect health-related quality of life (HRQOL). Topical treatments may help alleviate pain without risk of dependence or side effects. However, there is a lack of topical wound compounds targeting pain-specific receptors. One possible target is proinflammatory angiotensin 1 receptor (AT1R), which is upregulated in diabetic skin and has been implicated in nociception.