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Papers of the Week


Papers: 4 Feb 2023 - 10 Feb 2023

RESEARCH TYPE:
Review


Pharmacology/Drug Development

PAIN TYPE:
Migraine/Headache


2023 Feb


Cephalalgia


36759320


43


2

New migraine prophylactic drugs: Current evidence and practical suggestions for non-responders to prior therapy.

Authors

Lee MJ, Al-Karagholi MA, Reuter U

Abstract

Monoclonal antibodies against calcitonin gene-related peptide (CGRP) or its receptor (anti-CGRP(-R) mAbs) and small-molecule CGRP receptor antagonists (gepants) are new mechanism-based prophylactic drugs developed to address the unmet needs of pre-existing migraine prophylactic medications. However, several uncertainties remain in their real-world applications.