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Papers of the Week


Papers: 7 Sep 2024 - 13 Sep 2024


2024 Sep 09


Expert Opin Drug Metab Toxicol


39246127

Neurotoxicity testing: lessons from chemotherapy-induced peripheral neurotoxicity.

Authors

Tarasiuk O, Invernizzi C, Alberti P

Abstract

Chemotherapy induced peripheral neurotoxicity (CIPN) is a long-lasting, or even permanent, late toxicity caused by largely used anticancer drugs. CIPN affects a growing population of cancer survivors and diminishes their quality of life since there is no curative/preventive treatment. Among several reasons for this unmet clinical need, there is an incomplete knowledge on mechanisms leading to CIPN. Therefore, bench side research is still greatly needed: studies are pivotal to both evaluate neurotoxicity mechanisms and potential neuroprotection strategies.