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Papers of the Week


Papers: 25 Mar 2023 - 31 Mar 2023

RESEARCH TYPE:
Basic Science


Animal Studies, Molecular/Cellular

PAIN TYPE:
Inflammation/Inflammatory


2023


Front Mol Neurosci


36969557


16

Neuronal P2X4 receptor may contribute to peripheral inflammatory pain in rat spinal dorsal horn.

Authors

Ducza L, Gajtkó A, Hegedűs K, Bakk E, Kis G, Gaál B, Takács R, Szücs P, Matesz K, Holló K

Abstract

Intense inflammation may result in pain, which manifests as spinal central sensitization. There is growing evidence that purinergic signaling plays a pivotal role in the orchestration of pain processing. Over the last decade the ionotropic P2X purino receptor 4 (P2X4) got into spotlight in neuropathic disorders, however its precise spinal expression was scantily characterized during inflammatory pain. Thus, we intended to analyze the receptor distribution within spinal dorsal horn and lumbar dorsal root ganglia (DRG) of rats suffering in inflammatory pain induced by complete Freund adjuvant (CFA).