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Papers of the Week
Naloxone could limit morphine hypersensitivity: Considering the molecular mechanisms.
Authors
Baratzadeh M, Danialy S, Abtin S, Manaheji HAbstract
Naloxone has been used as an opioid antagonist to prevent multiple adverse side effects of opioid-like tolerance and hyperalgesia. This study has investigated naloxone combined with morphine to limit pain hypersensitivity. In addition, the expression of brain-derived neurotrophic factor (BDNF) and K Cl cotransporter2 (KCC2) were also studied.