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Papers of the Week
Myenteric plexus immune cell infiltrations and neurotransmitter expression in Crohn’s disease and ulcerative colitis.
Authors
Wiese JJ, Manna S, Kühl AA, Fascì A, Elezkurtaj S, Sonnenberg E, Bubeck M, Atreya R, Becker C, Weixler B, Siegmund B, Patankar JV, Prüß MS, Schumann MAbstract
Pain is a cardinal symptom in inflammatory bowel disease (IBD). An important structure in the transduction of pain signalling is the myenteric plexus (MP). Nevertheless, IBD-associated infiltration of the MP by immune cells lacks in-depth characterization. Herein we decipher intra- and periganglionic immune cell infiltrations in Crohn´s disease (CD) and ulcerative colitis (UC) and provide a comparison with murine models of colitis.