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Papers of the Week

Papers: 12 Aug 2023 - 18 Aug 2023

Basic Science

Animal Studies, Human Studies, Molecular/Cellular, Neurobiology

Abdominal/Pelvic Pain, Inflammation/Inflammatory

2023 Aug 11

J Crohns Colitis


Myenteric plexus immune cell infiltrations and neurotransmitter expression in Crohn’s disease and ulcerative colitis.


Wiese JJ, Manna S, Kühl AA, Fascì A, Elezkurtaj S, Sonnenberg E, Bubeck M, Atreya R, Becker C, Weixler B, Siegmund B, Patankar JV, Prüß MS, Schumann M


Pain is a cardinal symptom in inflammatory bowel disease (IBD). An important structure in the transduction of pain signalling is the myenteric plexus (MP). Nevertheless, IBD-associated infiltration of the MP by immune cells lacks in-depth characterization. Herein we decipher intra- and periganglionic immune cell infiltrations in Crohn´s disease (CD) and ulcerative colitis (UC) and provide a comparison with murine models of colitis.