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Papers of the Week


Papers: 13 Jan 2024 - 19 Jan 2024


2024 Feb 01


Anesth Analg


38215717


138


2

Multicenter Population Pharmacokinetics of Fentanyl in Neonatal Surgical Patients Using Dried Blood Spot Specimen Collection Demonstrates Maturation of Elimination Clearance.

Authors

Rzasa Lynn RS, Henthorn TK, Zuk J, Hammer GB, Drover DR, Levy RJ, Maxwell LG, Sadhasivam S, Suresh S, Galinkin JL

Abstract

Fentanyl is widely used for analgesia and sedation in neonates, but pharmacokinetic (PK) analysis in this population has been limited by the relatively large sample volumes required for plasma-based assays.