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Papers of the Week
Morphine treatment restricts response to immunotherapy in oral squamous cell carcinoma.
Authors
McIlvried LA, Martel Matos AA, Yuan MM, Atherton MA, Obuekwe F, Nilsen ML, Nikpoor AR, Talbot S, Bruno TC, Taggart DN, Johnson LK, Ferris RL, P Zandberg D, Scheff NNAbstract
Immune checkpoint inhibitors (ICIs) are becoming the standard of care for recurrent and metastatic cancer. Opioids, the primary treatment for cancer-related pain, are immunosuppressive raising concerns about their potential to interfere with the efficacy of ICIs. We hypothesize that exogenous opioids given for analgesia suppress antitumor immunity via T cell-mediated mu opioid receptor 1 (OPRM1) signaling.