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Papers of the Week

Papers: 23 Mar 2024 - 29 Mar 2024

2024 Mar 23

Nat Prod Res


Molecular docking of quercetin: a promising approach for the development of new anti-inflammatory and analgesic drugs.


Ettitaou A, Kabdy H, Oubella K, Raoui K, Oubahmane M, Aboufatima R, Elyazouli L, Garzoli S, Chait A


The aim of this study is to investigate the antinociceptive, anti-inflammatory and antipyretic effects of quercetin. Additionally, molecular docking studies were conducted to evaluate potential interactions between quercetin and various molecular targets. Animal models were used to conduct a comprehensive pharmacological investigation of quercetin. Evaluation of analgesic activity revealed a reduction in the number of abdominal cramps during the twisting test and inhibition of pain during the second phase of the formaldehyde test. Additionally, evaluation of its anti-inflammatory activity showed a reduction in ear oedema. However, it is important to note that quercetin administration has not been shown to significantly reduce yeast-induced hyperthermia. The docking study revealed the high inhibitory potential of quercetin against the COX-2 receptor.