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Papers of the Week

Papers: 4 Feb 2023 - 10 Feb 2023

Basic Science, Psychology

Animal Studies, Pharmacology/Drug Development

2022 Dec 21

Behav Pharmacol


Modeling spontaneous opioid withdrawal in male and female outbred mice using traditional endpoints and hyperalgesia.


Brewer AL, Lewis CC, Eggerman L, Blokker A, Burkland JA, Johnsen M, Quock RM


Opioid withdrawal significantly impacts drug dependence cycles as hyperalgesia associated with withdrawal is often a reason for continued drug use. Animal models of addiction are important tools for studying how drug dependence and withdrawal impact not only normal neurocircuitry but also the effectiveness of potential treatments for dependence and withdrawal. We conducted a study of the time course of spontaneous morphine withdrawal in outbred male and female mice that can be used to examine sex differences in male and female mice using both traditional somatic endpoints and mechanical hyperalgesia as an endpoint of withdrawal.