miR-374 family is a key regulator of chronic primary pain onset.
Authors
Hernandez NP, Rawls A, Chen J, Zhang X, Wang Y, Gao X, Parisien M, Karaky M, Meloto CB, Montagna F, Dang H, Pan Y, Zhao Y, McLean S, Linnstaedt S, Diatchenko L, Nackley AG
Abstract
Chronic primary pain conditions (CPPCs) are linked to catecholamine activation of peripheral adrenergic receptors. Yet, catecholamine-dependent epigenetic mechanisms, such as microRNA (miRNA) regulation of mRNA transcripts, remain largely unknown.
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