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Papers of the Week
Mild Exercise Expedites Joint Clearance and Slows Joint Degradation in a Joint Instability Model of Osteoarthritis in Male Rats.
Authors
Kaiser JM, Bernard FC, Pucha K, Raval SK, Eng T, Fulton T, Anderson SE, Allen KD, Brandon Dixon J, Willett NJAbstract
Exercise remains a hallmark treatment for post-traumatic osteoarthritis (PTOA) and may maintain joint homeostasis in part by clearing inflammatory cytokines, cells, and particles. It remains largely unknown whether exercise-induced joint clearance can provide therapeutic relief of PTOA. In this study, we hypothesized that exercise could slow progression of preclinical PTOA in part by enhancing knee joint clearance.