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Papers of the Week
Microglial Nrf2-mediated lipid and iron metabolism reprogramming promotes remyelination during white matter ischemia.
Authors
Zhang H, Yang S, Lu YL, Zhou LQ, Dong MH, Chu YH, Pang XW, Chen L, Xu LL, Zhang LY, Zhu LF, Xu T, Wang W, Shang K, Tian DS, Qin CAbstract
Oxidative stress and microglial activation are critical pathomechanisms in ischemic white matter injury. Microglia, as resident immune cells in the brain, are the main cells undergoing oxidative stress response. However, the role and molecular mechanism of oxidative stress in microglia have not been clearly elucidated during white matter ischemia.