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Papers of the Week


Papers: 18 Mar 2023 - 24 Mar 2023

RESEARCH TYPE:
Basic Science


Animal Studies, Molecular/Cellular, Neurobiology, Neuroimaging


2023 Mar 21


J Neuroinflammation


36944965


20


1

Microglia sustain anterior cingulate cortex neuronal hyperactivity in nicotine-induced pain.

Authors

Long DD, Zhang YZ, Liu A, Shen L, Wei HR, Lou QQ, Hu SS, Chen DY, Chai XQ, Wang D

Abstract

Long-term smoking is a risk factor for chronic pain, and chronic nicotine exposure induces pain-like effects in rodents. The anterior cingulate cortex (ACC) has been demonstrated to be associated with pain and substance abuse. This study aims to investigate whether ACC microglia are altered in response to chronic nicotine exposure and their interaction with ACC neurons and subsequent nicotine-induced allodynia in mice.