Browse by Audience
Skip to content
Papers of the Week
Microglia-Neuron Interactions Promote Chronic Itch via the NLRP3-IL-1β-GRPR Axis.
Authors
Liu X, Wang Y, Zeng Y, Wang D, Wen Y, Fan L, He Y, Zhang J, Sun W, Liu Y, Tao AAbstract
Spinal astrocytes contribute to chronic itch via sensitization of itch-specific neurons expressing gastrin-releasing peptide receptor (GRPR). However, whether microglia-neuron interactions contribute to itch remains unclear. In this study, we aimed to explore how microglia interact with GRPR neurons and promote chronic itch.