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Papers of the Week


Papers: 20 May 2023 - 26 May 2023

RESEARCH TYPE:
Basic Science


Animal Studies, In Vitro Studies, Neurobiology, Pharmacology/Drug Development

PAIN TYPE:
Cancer Pain, Neuropathic Pain


2023


Front Synaptic Neurosci


37216004


15

Metformin inhibits spontaneous excitatory postsynaptic currents in spinal dorsal cord neurons from paclitaxel-treated rats.

Authors

Liu TT, Qiu CY, Hu WP

Abstract

Cancer patients treated with paclitaxel often develop chemotherapy-induced peripheral neuropathy, which has not been effectively treated with drugs. The anti-diabetic drug metformin is effective in the treatment of neuropathic pain. The aim of this study was to elucidate effect of metformin on paclitaxel-induced neuropathic pain and spinal synaptic transmission.