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Papers of the Week


Papers: 11 Mar 2023 - 17 Mar 2023

RESEARCH TYPE:
Review


Neurobiology

PAIN TYPE:
Migraine/Headache


2023 Mar 13


Annu Rev Neurosci


36913712

Meningeal Mechanisms and the Migraine Connection.

Authors

Levy D, Moskowitz MA

Abstract

Migraine is a complex neurovascular pain disorder linked to the meninges, a border tissue innervated by neuropeptide-containing primary afferent fibers chiefly from the trigeminal nerve. Electrical or mechanical stimulation of this nerve surrounding large blood vessels evokes headache patterns as in migraine, and the brain, blood, and meninges are likely sources of headache triggers. Cerebrospinal fluid may play a significant role in migraine by transferring signals released from the brain to overlying pain-sensitive meningeal tissues, including dura mater. Interactions between trigeminal afferents, neuropeptides, and adjacent meningeal cells and tissues cause neurogenic inflammation, a critical target for current prophylactic and abortive migraine therapies. Here we review the importance of the cranial meninges to migraine headaches, explore the properties of trigeminal meningeal afferents, and briefly review emerging concepts, such as meningeal neuroimmune interactions, that may one day prove therapeutically relevant. Expected final online publication date for the , Volume 46 is July 2023. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.