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Papers of the Week

Papers: 1 Apr 2023 - 7 Apr 2023

Basic Science

Animal Studies, Molecular/Cellular, Neurobiology, Pharmacology/Drug Development

Abdominal/Pelvic Pain

2023 Mar 31

Mol Pain


Melatonin attenuated chronic visceral pain by reducing Na1.8 expression and nociceptive neuronal sensitization.


Lv MD, Wei YX, Chen JP, Cao MY, Wang QL, Hu S


Irritable bowel syndrome (IBS) is a common functional gastrointestinal disorder, and its specific pathogenesis is still unclear. We have previously reported that TTX-resistant (TTX-R) sodium channels in colon-specific dorsal root ganglion (DRG) neurons were sensitized in a rat model of visceral hypersensitivity induced by neonatal colonic inflammation (NCI). However, the detailed molecular mechanism for activation of sodium channels remains unknown. This study was designed to examine roles for Melatonin (MT) in sensitization of sodium channels in NCI rats.