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Papers: 1 Apr 2023 - 7 Apr 2023
RESEARCH TYPE:
Basic Science
Animal Studies, Molecular/Cellular, Neurobiology, Pharmacology/Drug Development
PAIN TYPE:
Abdominal/Pelvic Pain
2023 Mar 31
Mol Pain
Irritable bowel syndrome (IBS) is a common functional gastrointestinal disorder, and its specific pathogenesis is still unclear. We have previously reported that TTX-resistant (TTX-R) sodium channels in colon-specific dorsal root ganglion (DRG) neurons were sensitized in a rat model of visceral hypersensitivity induced by neonatal colonic inflammation (NCI). However, the detailed molecular mechanism for activation of sodium channels remains unknown. This study was designed to examine roles for Melatonin (MT) in sensitization of sodium channels in NCI rats.