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Papers of the Week
Maresin 1-LGR6 axis mitigates inflammation and posttraumatic osteoarthritis after transection of the anterior cruciate ligament in mice.
Authors
Leite CBG, Fricke HP, Tavares LP, Nshimiyimana R, Mekhail J, Kilgallen E, Killick F, Whalen JD, Lehoczky JA, Serhan CN, Charles JF, Lattermann CAbstract
Anterior cruciate ligament (ACL) tears frequently cause chronic inflammation and posttraumatic osteoarthritis (PTOA), with therapies failing to resolve persistent post-injury inflammation. Specialized pro-resolving mediators (SPMs), including Maresin1 (MaR1), show promise in resolving inflammation and promoting tissue repair. However, their role in PTOA remains underexplored. This study investigated inflammatory markers and MaR1 dynamics post-ACL injury, the role of the MaR1 receptor LGR6 in PTOA, and MaR1’s therapeutic potential in a mouse ACL transection (ACLT) model.