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Papers of the Week


Papers: 25 Feb 2023 - 3 Mar 2023

RESEARCH TYPE:
Clinical, Psychology


Human Studies, Neurobiology

PAIN TYPE:
Abdominal/Pelvic Pain, Psychological/Comorbidities


2023 Feb 06


World J Clin Cases


36818627


11


4

Major depressive disorders in patients with inflammatory bowel disease and rheumatoid arthritis.

Authors

Haider MB, Basida B, Kaur J

Abstract

Various immune-mediated inflammatory diseases consisting of inflammatory bowel disease (IBD) and rheumatoid arthritis (RA), are found to have a substantial societal burden, increased healthcare costs, and progressive disability. Studies suggest that patients with without comorbid depression have a more significant disability, a lower likelihood of remission, and reduced adherence to therapy. Elevated interleukin (IL)-1β, tumor necrosis factor-α, and IL-6 contribute to developing depression by the impaired physiological responses to stress, resulting in increased pain, fever, fatigue, and lack thereof of interest, and thus poor long-term outcomes. This study emphasizes the timely recognition of the prevalence of major depressive disorder (MDD) in patients with RA and IBD combined, thus preventing disability.