Home / Publications / Pain Research Forum / Papers of the Week / Lumbar endplate microfracture injury induces Modic-like changes, intervertebral disc degeneration and spinal cord sensitization – An In Vivo Rat Model.
Lumbar endplate microfracture injury induces Modic-like changes, intervertebral disc degeneration and spinal cord sensitization – An In Vivo Rat Model.
Authors
Wang D, Lai A, Gansau J, Seifert AC, Munitz J, Zaheer K, Bhadouria N, Lee Y, Nasser P, Laudier DM, Holguin N, Hecht AC, Iatridis JC
Abstract
Endplate (EP) injury plays critical roles in painful IVD degeneration since Modic changes (MCs) are highly associated with pain. Models of EP microfracture that progress to painful conditions are needed to better understand pathophysiological mechanisms and screen therapeutics.
