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Papers of the Week
Low-dose naltrexone for treatment of pain in patients with fibromyalgia: a randomized, double-blind, placebo-controlled, crossover study.
Authors
Bested K, Jensen LM, Andresen T, Tarp G, Skovbjerg L, Johansen TSD, Schmedes AV, Storgaard IK, Madsen JS, Werner MU, Bendiksen AAbstract
Fibromyalgia (FM) is a chronic fluctuating, nociplastic pain condition. Naltrexone is a µ-opioid-receptor antagonist; preliminary studies have indicated a pain-relieving effect of low-dose naltrexone (LDN) in patients with FM. The impetus for studying LDN is the assumption of analgesic efficacy and thus reduction of adverse effects seen from conventional pharmacotherapy.