I am a
Home I AM A Search Login

Papers of the Week

Papers: 3 Feb 2024 - 9 Feb 2024

2024 Mar

Osteoarthr Cartil Open




Low back pain patients with Modic type 1 changes exhibit distinct bacterial and non-bacterial subtypes.


Heggli I, Mengis T, Laux CJ, Opitz L, Herger N, Menghini D, Schuepbach R, Farshad-Amacker NA, Brunner F, Fields AJ, Farshad M, Distler O, Dudli S


Modic type 1 changes (MC1) are vertebral endplate bone marrow (BM) lesions observed on magnetic resonance images in sub-populations of chronic low back pain (CLBP) patients. The etiopathogenesis remains unknown and treatments that modify the underlying pathomechanisms do not exist. We hypothesized that two biological MC1 subtypes exist: a bacterial and a non-bacterial. This would have important implications for developing treatments targeting the underlying pathomechanisms.