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Papers of the Week


Papers: 8 Mar 2025 - 14 Mar 2025


2025 Mar 07


Sci Rep


40055490


15


1

Longitudinal study of central sensitization and chronic low back pain in a Japanese cohort during the COVID-19 pandemic.

Authors

Murata S, Hashizume H, Mure K, Oka H, Inoue S, Kanno S, Matsuyama Y, Ueno T, Murata A, Kido Y, Sonekatsu M, Shimoe T, Tamai H, Taiji R, Kozaki T, Teraguchi M, Enyo Y, Nakagawa Y, Miyai N, Yamada H

Abstract

This study utilized a longitudinal survey in Japan to investigate whether higher Central Sensitization Inventory (CSI) scores, serving as a proxy for central sensitization-related symptoms, are associated with an increased risk of developing chronic low back pain (CLBP), focusing on the impact of the coronavirus disease (COVID-19) pandemic on these conditions. Healthy volunteers (n = 227; mean age: 68.5 ± 9.5 years) were surveyed at baseline (July 2019) and at follow-up (October 2020). The participants were categorized into four groups based on their CLBP status: None, De novo, Continued, and Improved. CLBP prevalence increased from 26% at baseline to 32% at follow-up. Higher baseline CSI scores (odds ratio [OR] 1.05, 95% confidence interval [CI] 1.02-1.09; p = 0.005) and older age (OR 1.06, 95% CI 1.02-1.11; p = 0.007) were identified as significant risk factors for developing CLBP. The mean CSI scores exhibited a slight non-significant increase from 16.9 ± 11.4 to 17.1 ± 11.7. Participants who adhered more strictly to the COVID-19 guidelines and engaged in reduced physical activity reported a higher CLBP prevalence. Our findings suggest that early identification and management of central sensitization are crucial for improving clinical outcomes, particularly during periods of external stress, such as the COVID-19 pandemic.