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Papers of the Week


Papers: 20 Apr 2024 - 26 Apr 2024


2024 Apr 17


J Ethnopharmacol


38641072

Ligustilide covalently binds to Cys703 in the pre-S1 helix of TRPA1, blocking the opening of channel and relieving pain in rats with acute soft tissue injury.

Authors

Zhang K, Liu W, Shen F, Luan G, Han Y, Xu J, Fu C, Wu W, Hou Y, Jiang M, Zhang T, Bai G

Abstract

The natural anodyne Ligustilide (Lig), derived from Angelica sinensis (Oliv.) Diels and Ligusticum chuanxiong Hort., has been traditionally employed for its analgesic properties in the treatment of dysmenorrhea and migraine, and rheumatoid arthritis pain. Despite the existing reports on the correlation between TRP channels and the analgesic effects of Lig, a comprehensive understanding of their underlying mechanisms of action remains elusive.