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Papers of the Week


Papers: 25 Jan 2025 - 31 Jan 2025


2025 Jan


ACR Open Rheumatol


39853943


7


1

Ketogenic Diet-Associated Worsening of Osteoarthritis Histologic Secerity, Increased Pain Sensitivity and Gut Microbiome Dysbiosis in Mice.

Authors

Dyson G, Barrett M, Schlupp L, Prinz E, Hannebut N, Szymczak A, Brawner CM, Jeffries MA

Abstract

Dietary interventions are a potentially powerful treatment option for knee osteoarthritis (OA). The objective of this study was to evaluate a well-formulated ketogenic diet (KD) in the context of knee OA histology and pain using the destabilization of the medial meniscus (DMM) mouse model and correlate with gut microbiome and systemic cytokine levels.