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Papers of the Week


Papers: 25 Jan 2025 - 31 Jan 2025


2025 Jan 24


Brain Res Bull


39864595

JAK/STAT3 signaling promotes pain and depression-like behaviors in rats with bone cancer pain by regulating Th17 cell differentiation.

Authors

Wu S, Jiang J, Wang D, Lin D, Lin M, Chen P, Chen J, Zhang H, Wang Y, Chen X, Zheng X

Abstract

Pain and depression are common complications in patients with advanced cancer, which significantly affects their quality of life and survival. Dysregulation of the JAK/STAT3 pathway in the central nervous system is associated with pain and brain inflammatory disorders, but its role in bone cancer pain (BCP) remains unclear. This study aimed to investigate the specific role of the JAK/STAT3 pathway in the amygdala in BCP.