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Papers of the Week


Papers: 20 May 2023 - 26 May 2023

RESEARCH TYPE:
Clinical


Human Studies, Neurobiology, Pharmacology/Drug Development

PAIN TYPE:
Arthritis, Inflammation/Inflammatory


2023 May 22


Ann Rheum Dis


37217273

Irreversible covalent Bruton’s tyrosine kinase inhibitor, TAS5315 versus placebo in rheumatoid arthritis patients with inadequate response to methotrexate: a randomised, double-blind, phase IIa trial.

Authors

Takeuchi T, Tanaka S, Murata M, Tanaka Y

Abstract

To examine the efficacy and safety of TAS5315, an irreversible covalent Bruton’s tyrosine kinase inhibitor, in Japanese patients with rheumatoid arthritis (RA) refractory to methotrexate.