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Papers of the Week
IRF1 deficiency predisposes cartilage to accumulate DNA damage and promotes osteoarthritis development.
Authors
Cho Y, Kim H, Yook G, Yong S, Kim S, Lee N, Kim YJ, Kim JH, Kim TW, Chang MJ, Lee KM, Chang CB, Kang SB, Kim JHAbstract
Interferon regulatory factor 1 (IRF1) is a transcriptional regulator conventionally associated with immunomodulation. Recent molecular analyses mapping DNA binding sites of IRF1 have suggested its potential function in DNA repair. However, the physiological significance of this non-canonical function remains unexplored. Here, we investigated IRF1’s role in osteoarthritis (OA), a condition marked by senescence and chronic joint inflammation.