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Papers of the Week

Papers: 16 Mar 2024 - 22 Mar 2024

2024 Mar 18

Anesth Analg


Involvement of Spinal Neuroplastin 65 in Neuropathic Pain by GABAA Receptor α2 Subunit Regulation.


Xu L, Wang Y, Jiao Y, Huang Y, Xu R, Gu X, Zhang W, Ma Z


Neuropathic pain (NP) is a highly challenging condition with complex pathological mechanisms, and the spinal gamma aminobutyric acid A receptor receptor plays a crucial role in its progression. Recent studies have revealed a potential interaction between neuroplastin 65 (NP65) and gamma aminobutyric acid A receptor α2 subunit (GABAAR-α2) on the cell surface. We hypothesize that NP65 is involved in the pathogenesis of NP by regulating the level of GABAAR-α2.