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Papers of the Week

Papers: 29 Jul 2023 - 4 Aug 2023


Front Neurosci



Involvement of 5-HT receptors of the thalamic descending pathway in the analgesic effect of intramuscular heating-needle stimulation in a rat model of lumbar disc herniation.


Ma Y, Zhan Y, Pei J, Ye G, Chen Y, Zhu W, Shen H


Intramuscular (IM) heating-needle therapy, a non-painful thermal therapy, has been found to exert an analgesic effect the thalamic ventromedial (VM) nucleus, solely by reducing the triggering threshold for descending inhibition; this could be modulated by intracephalic 5-hydroxytryptamine-1A (5-HT) receptors, rather than via the regular analgesia pathway. In this study, the effect and the potential serotonergic mechanism of IM heating-needle stimulation at 43°C were explored in the case of the pathological state of lumbar disc herniation (LDH).