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Papers of the Week
Intraarticular monomethyl fumarate as a perspective therapy for osteoarthritis by macrophage polarization.
Authors
de Souza DM, Malange KF, Nishijima CM, de Melo Lima BH, Capetini VC, de Oliveira ALR, Anhê GF, Tambeli CH, Parada CAAbstract
Osteoarthritis (OA) is a chronic disease that may lead to joint structure degeneration, cartilage destruction, osteophyte formation, subchondral bone disruption, and pain. In this scenario, a higher proportion of the proinflammatory macrophage type 1 (M1) than the anti-inflammatory macrophage type 2 (M2) could be highlighted as a hallmark of OA progression. The balance between these two macrophage types emerges as a new therapeutic target in OA. This study aimed to evaluate the analgesia and macrophage profile in the treatment of experimental osteoarthritis (EOA) with systemic dimethyl fumarate (DMF) or local intra-articular monomethyl fumarate (MMF).