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Papers of the Week
Intra-articular sprouting of nociceptors accompanies progressive osteoarthritis: comparative evidence in four murine models.
Authors
Obeidat AM, Ishihara S, Li J, Adamczyk NS, Lammlin L, Junginger L, Maerz T, Miller RJ, Miller RE, Malfait AMAbstract
Knee joints are densely innervated by nociceptors. In human knees and rodent models, sprouting of nociceptors has been reported in late-stage osteoarthritis (OA). Here, we sought to describe progressive nociceptor remodeling in early and late-stage OA, using four distinct experimental mouse models.