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Papers of the Week
Inhibition of TRPM8 function by the prostacyclin receptor requires coupling to Gq/11 proteins.
Authors
Trif C, Banica AM, Manolache A, Anghel SA, Huţanu DE, Stratulat T, Badea R, Oprita G, Selescu T, Petrescu SM, Sisignano M, Offermanns S, Babes A, Tunaru SAbstract
The Transient Receptor Potential Melastatin subtype 8 (TRPM8) receptor-channel is involved in innocuous cold sensing and has a potent anti-inflammatory action. Its activation by lower temperature or chemical agonists such as menthol and icilin induces analgesic effects, reversing hypersensitivity and reducing chronic pain. On the other hand, prostacyclin (PGI ) enhances pain and inflammation by activating the prostacyclin receptor (IP-R). Due to the critical roles of TRPM8 and IP-R in the regulation of inflammatory pain, and considering their overlapping expression pattern, we analyzed the functional interaction between human TRPM8 and IP-R.