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Papers of the Week

Papers: 2 Dec 2023 - 8 Dec 2023

2023 Dec 03

Br J Pharmacol


Inhibition of TRPM8 function by the prostacyclin receptor requires coupling to Gq/11 proteins.


Trif C, Banica AM, Manolache A, Anghel SA, Huţanu DE, Stratulat T, Badea R, Oprita G, Selescu T, Petrescu SM, Sisignano M, Offermanns S, Babes A, Tunaru S


The Transient Receptor Potential Melastatin subtype 8 (TRPM8) receptor-channel is involved in innocuous cold sensing and has a potent anti-inflammatory action. Its activation by lower temperature or chemical agonists such as menthol and icilin induces analgesic effects, reversing hypersensitivity and reducing chronic pain. On the other hand, prostacyclin (PGI ) enhances pain and inflammation by activating the prostacyclin receptor (IP-R). Due to the critical roles of TRPM8 and IP-R in the regulation of inflammatory pain, and considering their overlapping expression pattern, we analyzed the functional interaction between human TRPM8 and IP-R.