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Papers of the Week
Inhibition of Phosphodiesterase 10A Alleviates Pain-like Behavior in Mice.
Authors
Gross T, Stehle D, Nagel C, Zhou F, Duman E, Hernandez-Olmos V, Sinderwald R, Gerninghaus H, Petersen J, Feil S, Kallenborn-Gerhardt W, Lu R, Metzner K, Feil R, Proschak E, Schmidtko AAbstract
Emerging evidence indicates that cyclic nucleotide phosphodiesterases exert distinct functions in pain processing and that targeting phosphodiesterases might be a novel strategy for pain relief. This study hypothesized that the phosphodiesterase isoform PDE10A might be a target for analgesic therapy.