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Papers of the Week
Inhibition of CXCR2 as a therapeutic target for chronic post-surgical pain: Insights from animal and cell models.
Authors
Zhao J, Jian C, Chen Z, Cai J, Zhou C, Li M, Yang Y, Gao YAbstract
Studies have shown that chemokines can stimulate the migration and activation of microglia to cause chronic post-surgical pain (CPSP). However, the involvement of C-X-C motif chemokine receptor 2 (CXCR2) as a new chemotactic factor in regulating CPSP and its underlying mechanism remains unclear. This study is to investigate the role of CXCR2 in the development of CPSP and reveal the underlying mechanism.