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Papers of the Week


Papers: 13 Jul 2024 - 19 Jul 2024


2024 Jul 16


J Headache Pain


39014318


25


1

Inhibition of 2-AG hydrolysis alleviates posttraumatic headache attributed to mild traumatic brain injury.

Authors

Wen J, Tanaka M, Zhang Y

Abstract

Posttraumatic headache (PTH) is a common and debilitating symptom following repetitive mild traumatic brain injury (rmTBI), and it mainly resembles a migraine-like phenotype. While modulation of the endocannabinoid system (ECS) is effective in treating TBI and various types of pain including migraine, the role of augmentation of endocannabinoids in treating PTH has not been investigated.