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Papers of the Week
Infusion of young donor plasma components in older patients modifies the immune and inflammatory response to surgical tissue injury: a randomized clinical trial.
Authors
Gaudilliere B, Xue L, Tsai AS, Gao X, McAllister TN, Tingle M, Porras G, Feinstein I, Feyaerts D, Verdonk F, Sabayev M, Hedou J, Ganio EA, Berson E, Becker M, Espinosa C, Kim Y, Lehallier B, Rawner E, Feng C, Amanatullah DF, Huddleston JI, Goodman SB, Aghaeepour N, Angst MSAbstract
Preclinical evidence suggests that young plasma has beneficial effects on multiple organ systems in aged mice. Whether young plasma exerts beneficial effects in an aging human population remains highly controversial. Despite lacking data, young donor plasma infusions have been promoted for age-related conditions. Given the preclinical evidence that young plasma exerts beneficial effects by attenuating inflammation, this study examined whether administering a young plasma protein fraction to an elderly population would exert anti-inflammatory and immune modulating effects in humans, using surgery as a tissue injury model.