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Papers of the Week
Inflammatory response of leptomeninges to a single cortical spreading depolarization.
Authors
Karan AA, Gerasimov KA, Spivak YS, Suleymanova EM, Vinogradova LVAbstract
Neurogenic meningeal inflammation is regarded as a key driver of migraine headache. Multiple evidence show importance of inflammatory processes in the dura mater for pain generation but contribution of the leptomeninges is less clear. We assessed effects of cortical spreading depolarization (CSD), the pathophysiological mechanism of migraine aura, on expression of inflammatory mediators in the leptomeninges.