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Papers of the Week
Inflammation dynamically regulates steroid hormone metabolism and action within macrophages in rheumatoid arthritis.
Authors
Martin CS, Crastin A, Sagmeister MS, Kalirai MS, Turner JD, MacDonald L, Kurowska-Stolarska M, Scheel-Toellner D, Taylor AE, Gilligan LC, Storbeck K, Price M, Gorvin CM, A F, Mahida R, Clark AR, Jones SW, Raza K, Hewison M, Hardy RSAbstract
In inflammatory diseases such as rheumatoid arthritis (RA), steroid metabolism is a central component mediating the actions of immuno-modulatory glucocorticoids and sex steroids. However, the regulation and function of cellular steroid metabolism within key leukocyte populations such as macrophages remain poorly defined. In this study, the inflammatory regulation of global steroid metabolism was assessed in RA macrophages.