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Papers of the Week

Papers: 29 Jun 2024 - 5 Jul 2024

2024 Jul 03

Clin Rheumatol


Inflammation as a therapeutic target for osteoarthritis: A literature review of clinical trials.


Zhu R, Fang H, Wang J, Ge L, Zhang X, Aitken D, Cai G


The burden of osteoarthritis (OA) is rapidly increasing with population aging, but there are still no approved disease-modifying drugs available. Accumulating evidence has shown that OA is a heterogeneous disease with multiple phenotypes, and it is unlikely to respond to one-size-fits-all treatments. Inflammation is recognized as an important phenotype of OA and is associated with worse pain and joint deterioration. Therefore, it is believed that anti-inflammatory treatments may be more effective for OA with an inflammatory phenotype. In this review, we summarized clinical trials that evaluated anti-inflammatory treatments for OA and discussed whether these treatments are more effective in inflammatory OA phenotypes compared to general OA patients.