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Papers of the Week
Induction of orofacial pain potentiates fibromyalgia symptoms in mice: Relevance of nociceptin system.
Authors
Volkweis MCC, Tomasi LA, Santos GC, Dagnino APA, Estrázulas M, Campos MMAbstract
Fibromyalgia patients might experience temporomandibular disorder (TMD) as a comorbidity. However, the connection between these two syndromes is not fully understood. Nociceptin (N/OFQ) and NOP receptors are implicated in both conditions, but their relevance in the comorbidity needs investigation. This study featured a comorbidity model of fibromyalgia plus TMD in mice, attempting to evaluate the significance of the N/OFQ-NOP receptor in this paradigm.