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Papers of the Week
Induction of cGMP-mediated migraine attacks is independent of CGRP receptor activation.
Authors
Raffaelli B, Do TP, Ashina H, Snellman J, Maio-Twofoot T, Ashina MAbstract
The cAMP and cGMP pathways are implicated in the initiation of migraine attacks, but their interactions remain unclear. Calcitonin gene-related peptide (CGRP) triggers migraine attacks via cAMP, whereas the phosphodiesterase-5 inhibitor sildenafil induces migraine attacks via cGMP. Our objective was to investigate whether sildenafil could induce migraine attacks in individuals with migraine pre-treated with the CGRP-receptor antibody erenumab.