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Papers of the Week
Inactivation of Tnf-α/Tnfr signaling attenuates progression of intervertebral disc degeneration in mice.
Authors
Tao C, Lin S, Shi Y, Gong W, Chen M, Li J, Zhang P, Yao Q, Qian D, Ling Z, Xiao GAbstract
Intervertebral disc degeneration (IVDD) is a major cause of low back pain (LBP), worsened by chronic inflammatory processes associated with aging. Tumor necrosis factor alpha (Tnf-α) and its receptors, Tnf receptor type 1 (Tnfr1) and Tnf receptor type 2 (Tnfr2), are upregulated in IVDD. However, its pathologic mechanisms remain poorly defined.