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Papers of the Week

Papers: 17 Feb 2024 - 23 Feb 2024

2024 Feb 19

Pharmacol Res


In Vitro Models for Neuropathic Pain Phenotypic Screening in Brain Therapeutics.


Martínez AL, Brea J, López D, Cosme N, Barro M, Monroy X, Burgueño J, Merlos M, Loza MI


The discovery of brain therapeutics faces a significant challenge due to the low translatability of preclinical results into clinical success. To address this gap, several efforts have been made to obtain more translatable neuronal models for phenotypic screening. These models allow the selection of active compounds without predetermined knowledge of drug targets. In this review, we present an overview of various existing models within the field, examining their strengths and limitations, particularly in the context of neuropathic pain research. We illustrate the usefulness of these models through a comparative review in three crucial areas: i) the development of novel phenotypic screening strategies specifically for neuropathic pain, ii) the validation of the models for both primary and secondary screening assays, and iii) the use of the models in target deconvolution processes. Phenotypic screening; immortalized cell lines; in vitro models; neuropathic pain; in vitro pharmacology; early drug discovery.