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Papers of the Week
Impact of SCN10A Polymorphism on Abdominal Pain Perception and Visceral Hypoalgesia in Crohn’s Disease and Ulcerative Colitis.
Authors
Coates MD, Walter V, Stuart A, Small J, Dalessio S, Carkaci-Salli N, Ouyang A, Clarke K, Tinsley A, Williams ED, Janicki P, Ruiz-Velasco V, Vrana KEAbstract
Hypoalgesic inflammatory bowel disease (IBD) may provide critical insights into human abdominal pain. This condition was previously associated with homozygosity for a polymorphism (rs6795970,A1073V;1073val/val) related to Nav1.8, a voltage-gated sodium channel preferentially expressed on nociceptors. It was unclear whether this relationship existed for both Crohn’s disease (CD) and ulcerative colitis (UC). This study evaluated a larger, carefully phenotyped IBD cohort to investigate this question.