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Papers of the Week
Impact of Chondrocyte Inflammation on Glial Cell Activation: The Mediating Role of Nitric Oxide.
Authors
Farrag M, Cordero-Barreal A, Ait Eldjoudi D, Varela-García M, Torrijos Pulpón C, Lago F, Essawy A, Soffar A, Pino J, Farrag Y, Gualillo OAbstract
This study investigates how the inflammatory response of ATDC5 murine chondrogenic cells influences the activity of C6 (rat) and GL261 (mouse) glial cell lines. Prior research suggested nitric oxide (NO) involvement in cartilage-immune crosstalk. The current study explores whether NO, produced by inflamed chondrocytes, mediates signaling between chondrocytes and glial cells.