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Papers of the Week

Papers: 29 Jun 2024 - 5 Jul 2024

2024 Jul 01

Osteoarthritis Cartilage


Immunomodulation and fibroblast dynamics driving nociceptive joint pain within inflammatory synovium: Unravelling Mechanisms for Therapeutic Advancements in Osteoarthritis.


Wijesinghe SN, Ditchfield C, Flynn S, Agrawal J, Davis ET, Dajas-Bailador F, Chapman V, Jones SW


Synovitis is a widely accepted sign of osteoarthritis (OA), characterised by tissue hyperplasia, where increased infiltration of immune cells and proliferation of resident fibroblasts adopt a pro-inflammatory phenotype, and increased the production of pro-inflammatory mediators that are capable of sensitising and activating sensory nociceptors, which innervate the joint tissues. As such it is important to understand the cellular composition of synovium and their involvement in pain sensitisation to better inform the development of effective analgesics.