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Papers of the Week

Papers: 22 Jun 2024 - 28 Jun 2024

2024 Jun 27

Curr Pain Headache Rep


Immune Competence and Pain: A Narrative Review.


Coaccioli S, Sarzi-Puttini P, Fornasari DMM, Schweiger V, Zis P, Viswanath O, Varrassi G


This review aims to summarize current knowledge on the pathophysiology of pain and the role of neuro-immune crosstalk in the development of acute and chronic pain (CP). Specifically, the review focuses on the role of immune cells involved in the innate and acquired immune response, emphasizing their bidirectional interactions with the nervous systems and discussing the implications of this crosstalk on acute and CP management.